hepatoprotective effect of otostegia persica boiss. shoot extract on carbon tetrachloride-induced acute liver damage in rats

Authors

sedighe nasiri bezenjani department of biology, school of sciences, shahid bahonar university of kerman, kerman, iran.

iran pouraboli department of biology, school of sciences, shahid bahonar university of kerman, kerman, iran.

reza malekpour afshar research center of physiology, kerman university of medical sciences, kerman, iran.

gholamabbas mohammadi department of biochemistry, medical school of afzalipour, kerman university of medical sciences, kerman, iran.

abstract

in this study, the hepatoprotective effect of the methanol extract of aerial parts (shoot) from otostegia persica boiss (golder) was investigated against the carbon tetrachloride (ccl4)-induced acute hepatotoxicity in male rats. liver damage was induced through the oral administration of 50% ccl4 in liquid paraffin (2.5 ml/kg bw, per os) 60 min after the administration of the methanol extract of o. persica shoot (in 200, 300, 400 mg/kg bw doses) and assessed using biochemical parameters (plasma and liver tissue malondialdehyde (mda), transaminase enzyme levels in plasma [aspartate transaminase (ast), alanine aminotransferase (alt)] and liver glutathione (gsh) levels). results show that the methanol extract of o. persica shoot is active at 300 mg/kg (per os) and it possess remarkable antioxidant and hepatoprotective activities. additionally, histopathological studies verified the effectiveness of this dose of extract in acute liver damage prevention.

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Journal title:
the iranian journal of pharmaceutical research

جلد ۱۱، شماره ۴، صفحات ۱۲۳۵-۱۲۴۱

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